Enzyme Patterns in Human Tissues. 3. Glycolytic Enzymes in Normal and Malignant Tissues of the Colon and Rectum.

tissues form a rational basis for the development of new cancer chemotherapeutic agents. These differences have been primarily uncovered and studied in rodent tumors and it seems essential to validate or invalidate the extra polation from rodent to human tumors by similar studies in human tumors (16). Ever since Warburg (18) reported the observation of a high rate of aerobic glycolysis in most malignant tissues, interest in the study of the enzymes of the glycolytic pathway in tumors has persisted. Although numerous studies on glycolytic enzymes have been reported for rodent tissues, only sporadic studies of a few of these en zymes have been reported for human tissues. An exten sive literature exists on such studies on body fluids. Re cently, Schmidt et al. (15) reported detailed data for these enzymes in human tissues but relatively few for malignant tissues. Methods of measurements and activity patterns of the glycolytic and some related enzymes for several